The ominous octet washington association of diabetes. A new paradigm for the treatment of type 2 diabetes mellitus ralph a. We now understand that there are 8 core defects in the human body that are currently known to adversely affect blood sugar levels in people with diabetes. Banting lecture from the triumvirate to the ominous.
Ppt ominous powerpoint presentation free to download. Pathogenesis of type 2 diabetes mellitus international. Insulin resistance in muscle and liver and impaired. A new paradigm for the treatment of type 2 diabetes mellitus. Decreased tcf7l2 protein levels in type 2 diabetes mellitus correlate with downregulation of gip and glp1 receptors and impaired betacell function. Schematic presentation of the gastrointestinal anatomy after. Prediabetes intermediate hyperglycaemia is a highrisk state for diabetes that is defined by glycaemic variables that are higher than normal, but lower than diabetes thresholds. Slides free downloadable slides for your reference and.
It is well established that type 2 diabetes t2d is a complex metaboliccardiovascular disorder with at least eight distinct pathophysiological disturbances, referred to as the ominous octet. It now is recognized that thecell failure occurs much earlier and is more severe than previously thought. Type 2 diabetes mellitus, which is far more common, affecting about 95% of all people diagnosed with diabetes, is a complex process of eight known possible defects known as the ominous octet. Over the past 20 years, during which increasing attention in the field of type 2 diabetes mellitus t2dm has focused on atherosclerotic complications, heart failure hf has emerged as another serious complication occurring significantly more frequently in people with t2dm. The natural history of type 2 diabetes described above is depicted by a prospective study carried out by felber and colleagues in lausanne, switzerland. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Collectively, these eight players comprise the ominous octet and dictate that 1 multiple drugs used in combination will be required to correct the multiple pathophysiological defects, 2 treatment should be based upon reversal of known pathogenic abnormalities and not simply on reducing hba 1c, and 3 therapy must be started early to. These can be used for reference purposes or for inclusion in ones. From ominous octet to dirty dozen sanjay kalra powerpoint ppt presentation. Bridging the gap from phase i to proofofconcept san francisco, ca tue 8th. Igt ominous octet type ii dm 8 mechanisms of hyperglycemia death. The ominous octet 3 depicting the mechanism and site of action of antidiabetes medications based upon the pathophysiologic disturbances present in t2dm. Ralph anthony defronzo, md presentation transcript. Ralph anthony defronzo, md ppt download slideplayer.
The ominous octet of dm2the ominous octet of dm2 islet. Insulin resistance in muscle and liver and impaired insulin secretion represent the core defects in type 2 diabetes. Banting lecture from the triumvirate to the ominous octet. Ominous octet and egregious eleven in 2009, the pathophysiology of diabetes was introduced as the omi nous octet, which challenged clinicians to think beyond impaired insulin secretion, increased hepatic glucose production, and. T2 a new paradigm for the treatment of type 2 diabetes mellitus. Dickinson is the diabetes education and management program director and lecturer at teachers college, columbia university in new york, n. View ominous octet ppts online, safely and virusfree. Download figure open in new tab download powerpoint. Defronzo i nsulin resistance in muscle and liver and cell failure represent the core pathophysiologic defects in type 2 diabetes. Patients aged 18 years and older, with type 2 diabetes, an estimated glomerular filtration rate of 3059 mlmin per 173 m 2, and who had been receiving a stable dose of metformin or sulfonylurea, or both, or basal insulin with or without metformin for the past 90 days were eligible. Defronzo from the diabetes division, university of. Pathogenesis of type 2 diabetes the ominous octet islet bcell impaired insulin secretion neurotransmitter dysfunction decreased glucose uptake islet acell increased glucagon secretion increased. Pathophysiologic approach to therapy in patients with.
Diabetes is manysided and were learning more about it all the time. Pathophysiology of type 2 diabetes bruno almeida m. Therapy of type 2 diabetes mellitus, update, part 1. Living with diabetes this booklet provides information about the steps to managing diabetes by eating healthy, being active, and taking medicines. Funnell is an emeritus research scientist with the department of learning health sciences at the university of michigan medical school in ann arbor, mich. Dr ralph defronzo discusses eight core defects implicated in the pathogenesis of type 2 diabetes as described during his ominous octet banting lecture presented in 2008. Ppt from ominous octet to dirty dozen sanjay kalra powerpoint.
Professor of medicine and chief, diabetes division, the university of texas health science center at san antonio uthscsa, deputy director, texas diabetes institute, san antonio, tx, usa. The ominous octet defronzo r diabetes 2009 metformin ampk. These can be used for reference purposes or for inclusion in ones own slide sets. American diabetes association professor of medicine georgetown university school of medicine disclosed no conflict of interest newer therapies. This randomised, doubleblind, phase 3a trial was undertaken at 88 sites in eight countries. Novel agents for the treatment of type 2 diabetes from 1987 to the present, our understanding of the pathophysiology of type 2 diabetes has expanded from the triumvirate of. Cut out the notecards by cutting along each horizontal dotted. The word ominous suggests that something bad or unfortunate may happen in the future. The ominous octet outlined in orange are the three core pathophysiologies of type 2 diabetes, known as the triumvirate.
Downloadable powerpoint slides that summarizeillustrate topics pertinent to diabetes care. Winner of the standing ovation award for best powerpoint templates from presentations magazine. In people with type 2 diabetes, there are at least 8 core defects that can affect blood sugar levels. Includes an overview of diabetes treatment options. New paradigm for the treatment of type 2 diabetes mellitus. From 1987 to the present, our understanding of the pathophysiology of type 2 diabetes has expanded from the triumvirate of. Doctors and scientists call these 8 core defects the ominous octet. Prevalence of type 2 diabetes mellitus t2dm, the ominous octet of hyperglycemia in type 2 diabetes mellitus, mechanisms of insulin resistance, diagnostic. To compare recent diabetes guideline updates from the american diabetes associationeuropean association for the study of diabetes. These defects, called the ominous octet, can cause diabetes to change over time and make it difficult to reach your a1c goal. Stanley schwartzs slides series on the state of diabetes in the u. The ominous octet core defects in type 2 diabetes pro.
Dr ralph defronzo discusses 8 core defects implicated in the pathogenesis of type 2 diabetes as described during his ominous octet banting lecture presented in 2008. Hf is typically an ominous diagnosis in patients with diabetes. The multiple complex pathophysiologic defects associated with type 2 diabetes mellitus require that multiple drugs be used in combination to improve the patients overall outcomes, and that treatment should be based on reversal of all known complications, rather than strictly on reducing a1c. Diabetes presentation 2018 by prezi user on prezi next. Relate common adverse drug effects of current diabetes pharmacotherapy to key side effects that should be minimized based on national guidelines. Displaying powerpoint presentation on the eight core defects in type 2 diabetesthe ominous octet available to view or download. In general, if you have type 2 diabetes, the risk of your child getting diabetes is 1 in 7 if you were diagnosed before age 50 and 1 in if you were diagnosed after age 50. Pioglitazone, diabetes mellitus, type 2 and piperidines researchgate, the. The time is right for a new classification system for diabetes.
Although the study was originally crosssectional in nature, subjects were followed up for 6 years and shown to progress from one category of glucose intolerance to the next. Print diabetes ominous octet flashcards easy notecards. Two general approaches to the treatment of type 2 diabetes mellitus t2dm have been advocated. Find powerpoint presentations and slides using the power of, find free presentations research about defronzo ppt. New paradigm for the treatment of type 2 diabetes mellitus misha denham, d. Some scientists believe that a childs risk is greater when the parent with type 2 diabetes is the mother. Hyperglycemia is a manifestation of these eight pathophysiological abnormalities.
Resource preservation of pancreatic betacell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in highrisk hispanic women. Efficacy and safety of oral semaglutide in patients with. Identify current and emerging pharmacotherapy treatments for type 2 diabetes. Edcs and diabetes exposure to ddt in utero can increase a childs risk of. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. From the triumvirate to the ominous octet a new paradigm for the treatment of t2dm. Find powerpoint presentations and slides using the power of, find free presentations research about ominous octet ppt. Fold each page in half along the solid vertical line. Diabetes pathophysiology the video demonstrates the mechanism of glp1 and insulin in a simplified, funtolearn manner for clinicians. Collectively, these eight players comprise the ominous octet and dictate that. Print diabetes ominous octet flashcards and study them anytime, anywhere.
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